gary graviton: December 2011

Monday, December 5, 2011

[OOC] Skyrim: Brotherhood

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.
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POWER TO THE ROLE PLAYERS

i am 33% evil, 33% insane, 33% role player, and 1% other (Note: Insane and Brilliant are the same thing!)

My test:

My Brothers Test: [CENTER]

Mr. Baneling Squishy: Member for 1 years

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Sunday, December 4, 2011

technosailor: @jrcornthwait I don't know why Twitter collectively got hungry just now

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Saturday, December 3, 2011

Not all cellular reprogramming is created equal

ScienceDaily (Dec. 1, 2011) ? Tweaking the levels of factors used during the reprogramming of adult cells into induced pluriopotent stem (iPS) cells greatly affects the quality of the resulting iPS cells, according to Whitehead Institute researchers.

"This conclusion is something that I think is very surprising or unexpected -- that the levels of these reprogramming factors determine the quality of the iPS cells," says Whitehead Founding Member Rudolf Jaenisch. "We never thought they'd make a difference, but they do."

An article describing this work is published in the December 2 issue of Cell Stem Cell.

iPS cells are made by introducing specific reprogramming genes into adult cells. These factors push the cells into a pluripotent state similar to that of embryonic stem (ES) cells. Like ES cells, iPS cells can become any cell type in the body, a characteristic that could make them well-suited for therapeutic cell transplantation or for creating cell lines to study such diseases as Parkinson's and Alzheimer's.

Since the creation of the first iPS cells in 2006, researchers using various reprogramming techniques have reported a broad spectrum of efficiency rates and quality of resulting iPS cells. Although researchers have shown iPS cells can fulfill all developmental tests applied to ES cells, recent reports have identified molecular differences that can influence their developmental potential and render them less-than-equivalent partners to ES cells. These inconsistencies have tarnished the promise of iPS cells, dampened enthusiasm, and fueled speculation that they may never be used therapeutically.

In one example reported last year, a lab created iPS cells using a cutting-edge technique in which a piece of DNA containing four reprogramming genes is safely integrated in the genome of adult mouse cells. In this highly publicized study, the resulting iPS cells performed poorly in tests of pluripotency and failed to produce adult mice, which is the most stringent test of pluripotency. Yet again this called into question the fidelity by which reprogramming factors could consistently generate fully reprogrammed cells equivalent to ES cells. Many in the field saw this as another nail in the coffin of iPS cells.

To Bryce Carey, first author of the Cell Stem Cell paper and a graduate student in Jaenisch's lab at the time, this death knell seemed premature. He repeated the experiment, changing a few details, including the order in which the reprogramming factors were placed on the inserted piece of DNA. Surprisingly, such small alterations had a profound effect -- more adult cells were converted to high-quality iPS cells than in the earlier, nearly identical study.

"We are trying to show that the reprogramming process is not as flawed as some have thought, and that you can isolate these fully pluripotent iPS cells that have all of the developmental potential as embryonic stem cells at a pretty high frequency," says Carey, who is now a postdoctoral associate at Rockefeller University. "A lot of times these parameters are very difficult to control, so while the approach first described by [Shinya] Yamanaka back in 2006 is still the most reliable method for research purposes, we should be cautious in concluding there are inherent limitations. We show recovery of high-quality cells doesn't have to be the exception."

This work was supported by the National Science Foundation (NSF) and the National Institutes of Health (NIH).

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The above story is reprinted from materials provided by Whitehead Institute for Biomedical Research.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Bryce W. Carey, Styliani Markoulaki, Jacob H. Hanna, Dina A. Faddah, Yosef Buganim, Jongpil Kim, Kibibi Ganz, Eveline J. Steine, John P. Cassady, Menno P. Creyghton et al. Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells. Cell Stem Cell, 2 December 2011; 9(6) pp. 588 - 598 DOI: 10.1016/j.stem.2011.11.003

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111201125151.htm

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Two out of three medical students do not know when to wash their hands

ScienceDaily (Dec. 1, 2011) ? Only 21 percent of surveyed medical students could identify five true and two false indications of when and when not to wash their hands in the clinical setting, according to a study published in the December issue of the American Journal of Infection Control, the official publication of APIC -- the Association for Professionals in Infection Control and Epidemiology.

Three researchers from the Institute for Medical Microbiology and Hospital Epidemiology at Hannover Medical School in Hannover, Germany collected surveys from 85 medical students in their third year of study during a lecture class that all students must pass before bedside training and contact with patients commences. Students were given seven scenarios, of which five ("before contact to a patient," "before preparation of intravenous fluids," "after removal of gloves," "after contact to the patient's bed," and "after contact to vomit") were correct hand hygiene (HH) indications. Only 33 percent of the students correctly identified all five true indications, and only 21 percent correctly identified all true and false indications.

Additionally, the students expected that their own HH compliance would be "good" while that of nurses would be lower, despite other published data that show a significantly higher rate of HH compliance among nursing students than among medical students. The surveyed students further believed that HH compliance rates would be inversely proportional to the level of training and career attainment of the physician, which confirms a previously discovered bias among medical students that is of particular concern, as these higher-level physicians are often the ones training the medical students at the bedside.

"There is no doubt that we need to improve the overall attitude toward the use of alcohol-based hand rub in hospitals," conclude the authors. "To achieve this goal, the adequate behavior of so-called 'role models' is of particular importance."

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The above story is reprinted from materials provided by Elsevier, via AlphaGalileo.

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Journal Reference:

K. Graf and I.F. Chaberny, R.-P. Vonberg. Beliefs about hand hygiene: A survey in medical students in their first clinical year. American Journal of Infection Control, Volume 39, Issue 10 (December 2011)

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://www.sciencedaily.com/releases/2011/12/111201105445.htm

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Friday, December 2, 2011

NASA's Nanosail-D 'sails' home -- mission complete

ScienceDaily (Nov. 29, 2011) ? After spending more than 240 days "sailing" around Earth, NASA's NanoSail-D -- a nanosatellite that deployed NASA's first-ever solar sail in low-Earth orbit -- has successfully completed its Earth orbiting mission.

Launched to space Nov. 19, 2010 as a payload on NASA's FASTSAT, a small satellite, NanoSail-D's sail deployed on Jan. 20.

The flight phase of the mission successfully demonstrated a deorbit capability that could potentially be used to bring down decommissioned satellites and space debris by re-entering and totally burning up in Earth's atmosphere. The team continues to analyze the orbital data to determine how future satellites can use this new technology.

A main objective of the NanoSail-D mission was to demonstrate and test the deorbiting capabilities of a large low mass high surface area sail.

"The NanoSail-D mission produced a wealth of data that will be useful in understanding how these types of passive deorbit devices react to the upper atmosphere," said Joe Casas, FASTSAT project scientist at NASA's Marshall Space Flight Center in Huntsville, Ala.

"The data collected from the mission is being evaluated, said Casas, in conjunction with data from FASTSAT science experiments intended to study and better understand the drag influences of Earth's upper atmosphere on satellite orbital re-entry."

The FASTSAT science experiments are led by NASA's Goddard Space Flight Center in Greenbelt, Md. and sponsored by the Department of Defense Space Experiments Review Board which is supported by the Department of Defense Space Test Program.

Initial assessment indicates NanoSail-D exhibited the predicted cyclical deorbit rate behavior that was only previously theorized by researchers.

"The final rate of descent depended on the nature of solar activity, the density of the atmosphere surrounding NanoSail-D and the angle of the sail to the orbital track," said Dean Alhorn, principal investigator for NanoSail-D at Marshall Space Flight Center. "It is astounding to see how the satellite reacted to the sun's solar pressure. The recent solar flares increased the drag and brought the nanosatellite back home quickly."

NanoSail-D orbited Earth for 240 days performing well beyond expectations and burned up during reentry to Earth's atmosphere on Sept. 17.

NASA formed a partnership with Spaceweather.com to engage the amateur astronomy community to submit images of the orbiting NanoSail-D solar sail during the flight phase of the mission. NanoSail-D was a very elusive target to spot in the night sky -- at times very bright and other times difficult to see at all. Many ground observations were made over the course of the mission. The imaging challenge concluded with NanoSail-D's deorbit. Winners will be announced in early 2012.

For more information, visit: http://www.nanosail.org/

The NanoSail-D experiment was managed at the Marshall Center, and designed and built by engineers in Huntsville. Additional design, testing, integration and execution of key spacecraft bus development and deployment support operation activities were conducted by engineers at NASA's Ames Research Center in Moffett Field, Calif. The experiment is the result of a collaborative partnership between NASA; the Department of Defense Space Test Program, and the U.S. Army Space and Missile Defense Command, the Von Braun Center for Science and Innovation, Dynetics Inc. and Mantech Nexolve Corp.

For more information about NanoSail-D visit: http://www.nasa.gov/mission_pages/smallsats/nanosaild.html

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/sfB-XI7hHRk/111129183126.htm

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